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Blood pressure changes resulting from aortography
Insights
Conventional ionic contrast media cause significant hypotension in patients with arteriosclerosis undergoing aortography. Non-ionic contrast media, like metrizamide, result in less severe and shorter-lasting blood pressure drops.
Area of Science:
- Cardiovascular medicine
- Radiology
- Pharmacology
Background:
- Patients undergoing aortography often have generalized arteriosclerosis.
- Uncontrolled hypotension is a significant risk, particularly with myocardial depression.
Purpose of the Study:
- To compare the hemodynamic effects of conventional ionic contrast media versus a non-ionic contrast medium during aortography.
Main Methods:
- Patients received conventional ionic contrast media (Urografin 370, Cardioconray) or metrizamide (non-ionic).
- Blood pressure changes and duration of hypotension were monitored after each injection.
Main Results:
- Conventional ionic contrast media caused significant hypotension in all patients.
- Metrizamide was associated with a less pronounced and shorter duration of blood pressure decrease.
Conclusions:
- Non-ionic contrast media, such as metrizamide, offer a safer alternative to ionic media for aortography in patients with arteriosclerosis due to reduced hypotensive effects.
Abstract:
Patients requiring aortography frequently suffer from generalized arteriosclerosis. Uncontrolled hypotension is therefore clearly undesirable, especially if associated with myocardial depression. Significant hypotension was observed following the use of conventional ionic contrast media, Urografin 370 and Cardioconray, and occurred following every injection in this study. Metrizamide, a non-ionic contrast medium, was found to be associated with a smaller fall in blood pressure of a shorter duration.