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Updated: Jul 30, 2026
13:32
Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
Published on: January 14, 2014
Pulmonary veno-occlusive disease. Morphological changes suggesting a viral cause
JAMA
|August 7, 1981
Summary
Pulmonary veno-occlusive disease, a rare condition, can cause acute respiratory failure and is linked to cerebral vasculitis. This case highlights its consideration in patients with unexplained pulmonary hypertension and fibrosis.
Area of Science:
- Medicine
- Pathology
- Pulmonology
Background:
- A 47-year-old male with industrial exposure and interstitial lung disease presented with acute decompensation.
- The patient experienced severe dyspnea, fever, hypoxemia, and elevated pulmonary arterial pressures.
Observation:
- Autopsy revealed a selective veno-occlusive process as the cause of pulmonary issues.
- Pulmonary phlebitis was accompanied by cerebral vasculitis and enlarged lymph nodes with erythrophagocytosis.
Findings:
- The findings suggest a potential underlying viral infection contributing to the observed pathology.
- Pulmonary veno-occlusive disease (PVOD) was identified as the primary pulmonary issue.
Implications:
- PVOD should be considered in differential diagnoses for pulmonary fibrosis and hypertension.
- This case underscores the importance of considering PVOD in patients with cor pulmonale and normal left atrial pressures.
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