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Enhancement of melphalan therapy with glutaminase:asparaginase
Research Communications in Chemical Pathology and Pharmacology
|October 1, 1978
Abstract:
Depletion of glutamine with Acinetobacter glutaminase:asparaginase promotes melphalan uptake by and cytotoxicity to murine L1210 cells in vitro. Combined treatment of tumor bearing mice with these two agents increases the therapeutic response.
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