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Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
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[Hemoglobin affinity for oxygen in the blood draining from the heart]

M V Borisiuk

    Kardiologiia
    |April 1, 1981
    PubMed

    The difference in hemoglobin affinity for oxygen in blood of the coronary sinus and in mixed venous blood was shown in dog experiments. The lower affinity of hemoglobin for blood flowing from the heart causes greater deoxidation of oxyhemoglobin. Following injection into the body of adrenaline which activates the adenylyl cyclase system, the oxyhemoglobin dissociation curve of coronary sinus blood is displaced to the left. On the grounds of in vitro experiments it is suggested that this effect is mediated by adenosine 3,5-cyclic monophosphate entering the blood. The author discusses the importance of the flow rate of blood and adenosine 3,5-cyclic monophosphate as factors responsible for the specific features of the regulation of hemoglobin affinity to oxygen within organs and the possible ethiopathogenetic significance of increased hemoglobin affinity for oxygen in the development of myocardial hypoxia.

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