[Pattern quantification of coronary artery stenosis by computerized analysis of multiple ECG parameters (author's...

Coronary angiograms of 200 patients with coronary artery disease were studied. The distribution of stenoses was analyzed and classified utilizing a special score, taking into account coronary supply pattern (according to Baroldi et al.), localization and severity of stenosis, as well as collateralization. Frank-lead vectorcardiograms were obtained and analyzed by computer. 140 scalar and spatial vector parameters were evaluated. A statistical comparison was made in 36 patients with highgrade stenoses of the left anterior descending branch of the left coronary artery with 37 patients without such vascular narrowing. Utilizing 4 ECG-parameters a mathematical formula can be derived which separates the two groups. Another equation based on 5 parameters allows the calculation of a score from conventional electrocardiograms. By discriminance analysis a specificity of 78.4% and a sensibility of 77.8 in prediction results for the group with stenosis. For the control group a specificity of 75.7% and a sensibility of 77.8% were computed. Correlation between the score obtained by calculation on the one hand, and the score derived from direct analysis of the arteriogram was highly significant with an r = 0.796.