Related Experiment Videos
[Candida infection of gastric ulcers. 6 cases (author's transl)]
Abstract:
Candida infection of mild gastric ulcers was detected by gastric biopsy in 6 patients aged from 67 to 82 years. Filaments and spores were located in the connective tissue or submucosa in 3 cases and in the false membrane in the other 3. No predisposing cause was found in 5 patients. Chemical study of the gastric secretion was performed in all patients under maximal pentagastrin stimulation and showed normal acidity. The addition of amphotericin B to the anti-ulcerous treatment seems to have helped the ulcer to heal.
Insights
Candida infection was found in elderly patients with gastric ulcers. Antifungal treatment with amphotericin B aided ulcer healing, suggesting a role for Candida in gastric ulcer pathology.
Area of Science:
- Gastroenterology
- Mycology
- Infectious Diseases
Background:
- Gastric ulcers are common, but secondary infections can complicate healing.
- The role of fungal infections, specifically Candida, in gastric ulcer pathogenesis is not well-established.
Observation:
- Six elderly patients (67-82 years) with mild gastric ulcers were identified with Candida infection via gastric biopsy.
- Fungal elements (filaments and spores) were observed in submucosa or false membranes.
- No clear predisposing factors were identified in most patients.
Findings:
- Gastric secretion analysis revealed normal acidity under maximal stimulation.
- Patients received standard anti-ulcer treatment alongside amphotericin B.
- The addition of amphotericin B appeared to facilitate ulcer healing.
Implications:
- Candida species may contribute to the development or delayed healing of gastric ulcers in certain populations.
- Antifungal therapy could be a beneficial adjunct treatment for gastric ulcers with suspected fungal involvement.
- Further research is warranted to elucidate the mechanisms of Candida-associated gastric ulcers.