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The vagogastrone mechanism in man
Scandinavian Journal of Gastroenterology
|January 1, 1978
Summary
Vagogastrone, a potential hormone that inhibits gastric acid secretion, was investigated in humans. Vagal activation showed a minor, short-lived inhibitory effect in duodenal ulcer patients, suggesting a limited role in gastric acid regulation.
Area of Science:
- Gastroenterology
- Neurogastroenterology
- Endocrinology
Background:
- Evidence suggests a vagal hormone, vagogastrone, inhibits gastric acid secretion.
- Vagogastrone's role is primarily observed against gastrin-stimulated secretion in denervated parietal cells.
- The precise nature and origin of vagogastrone remain undetermined.
Purpose of the Study:
- To investigate the existence and effect of vagogastrone in humans.
- To assess the impact of vagal activation on pentagastrin-stimulated gastric acid secretion.
Main Methods:
- Seven duodenal ulcer patients who underwent proximal gastric vagotomy were studied.
- Vagal activation was achieved through sham feeding.
- Gastric acid secretion was stimulated by continuous intravenous pentagastrin infusion.
Main Results:
- Sham feeding resulted in a modest 16% reduction in acid secretion in patients with prior vagotomy.
- This inhibitory effect was transient.
- Sham feeding did not alter pentagastrin-stimulated acid secretion in individuals with intact stomachs.
Conclusions:
- The findings support the existence of a vagogastrone mechanism in humans.
- The quantitative importance of this inhibitory mechanism appears minimal, particularly in duodenal ulcer patients.