Acute toxicity of methotrexate and cyclophosphamide in mice inoculated with malignant neoplasms

The toxicity of methotrexate and cyclophosphamide determined by LD50 was depressed in the early period of development of sarcoma Sa-180. In the late period of development of Sa-180 and in mice with leukemia L-1210 the toxicity was higher than in healthy mice. The growth of transplantable neoplasms leads to cachexia, hypoproteinemia and dysproteinemia.