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Meptazinol and morphine compared: a study using systolic time intervals

M de Rosayro, T E Healy, G K Morris

    Pharmatherapeutica
    |January 1, 1981
    PubMed
    Summary
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    Morphine administration showed potential negative inotropic effects on cardiac performance in surgical patients. Meptazinol, however, consistently improved ventricular performance, indicating a safer cardiac profile in this context.

    Area of Science:

    • Anesthesiology
    • Cardiology
    • Pharmacology

    Background:

    • Intra-abdominal operations necessitate careful anesthetic management.
    • Assessing the cardiac effects of analgesics like morphine and meptazinol is crucial in surgical patients.

    Purpose of the Study:

    • To compare the effects of morphine and meptazinol on cardiac performance in patients undergoing intra-abdominal surgery.
    • To evaluate potential negative inotropic effects versus improved ventricular function.

    Main Methods:

    • Systolic time intervals were measured in 12 patients.
    • Patients received either morphine (0.1 mg/kg) or meptazinol (1 mg/kg).
    • Changes in cardiac performance indices were analyzed post-administration.

    Main Results:

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    • Both drugs induced small changes in cardiac performance indices.
    • Morphine administration (n=6) suggested negative inotropism in 5 patients.
    • Meptazinol administration (n=6) consistently suggested improved ventricular performance.

    Conclusions:

    • Morphine may exert negative inotropic effects during intra-abdominal surgery.
    • Meptazinol appears to offer a beneficial effect on ventricular performance in this surgical setting.
    • Further research into meptazinol's cardiac profile in surgical anesthesia is warranted.