Response of rat liver aspartate aminotransferase to carbon tetrachloride

Rat liver aspartate aminotransferase activity per total liver per gram initial body weight was increased 24 hours after carbon tetrachloride injection suggesting that increased synthesis may be a source of increased serum enzyme activity as a response to hepatocellular injury. Protein content per total liver per gram initial body weight was also increased so that the specific activity of the enzyme was unchanged. Enzyme activity per gram liver wet weight was decreased consistent with hepatomegaly, edema, and dilution of enzyme. Total liver per gram initial body weight is suggested as the optimal reference standard.