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Negative test for transplacental carcinogenicity of nickel subsulfide in Fischer rats
Transplacental carcinogenicity of nickel subsulfide (Ni3S2) was tested by im administration of Ni3S2 (20 mg) to 8 pregnant Fischer rats on day 6 of gestation. Control dams received a similar injection of the vehicle. The progeny at risk for tumor development comprised 50 offspring (17 males, 33 females) of Ni3S2-treated dams and 53 offspring (29 males, 24 females) of control dams. Body weights of progeny of Ni3S2 treated dams were lower than progeny of control dams, but sex-specific cumulative mortality rates in the two groups did not differ significantly. By age 26 months, 2 malignant and 2 benign tumors developed in progeny of Ni3S2-treated dams, versus 3 malignant and 2 benign tumors in progeny of control dams. Hence, administration of Ni3S2 to pregnant rats had no significant effect upon tumor incidence in the progeny.
Transplacental carcinogenicity of nickel subsulfide (Ni3S2) was tested by im administration of Ni3S2 (20 mg) to 8 pregnant Fischer rats on day 6 of gestation. Control dams received a similar injection of the vehicle. The progeny at risk for tumor development comprised 50 offspring (17 males, 33 females) of Ni3S2-treated dams and 53 offspring (29 males, 24 females) of control dams. Body weights of progeny of Ni3S2 treated dams were lower than progeny of control dams, but sex-specific cumulative mortality rates in the two groups did not differ significantly. By age 26 months, 2 malignant and 2 benign tumors developed in progeny of Ni3S2-treated dams, versus 3 malignant and 2 benign tumors in progeny of control dams. Hence, administration of Ni3S2 to pregnant rats had no significant effect upon tumor incidence in the progeny.