Related Experiment Videos
Cardiac effects of clonidine on isolated dog atria
The Tohoku Journal of Experimental Medicine
|April 1, 1981
Abstract:
The effect of clonidine on pacemaker activity and contractility was studied in the isolated dog atrium which was perfused with arterial blood of the support dog. Clonidine caused dose-dependent negative chronotropic and inotropic effects, and a large dose of clonidine slightly suppressed the positive chronotropic and inotropic responses to norepinephrine and sympathetic cardiac nerve stimulation (5 and 30 Hz) but not consistently.