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[Oxidation reduction processes in skin with psoriasis]
Ukrainskii Biokhimicheskii Zhurnal (1978)
|September 1, 1980
Summary
Psoriasis skin shows increased redox processes affecting respiratory enzymes. These enzyme activity disturbances persist even after clinical recovery, indicating lasting metabolic changes.
Area of Science:
- Biochemistry
- Dermatology
- Cellular Metabolism
Context:
- Psoriasis is a chronic inflammatory skin condition.
- Altered cellular metabolism is implicated in psoriasis pathogenesis.
- Oxidative stress plays a role in inflammatory diseases.
Purpose:
- To investigate the intensity of redox processes in psoriatic skin.
- To evaluate the activity of respiratory chain enzymes in psoriasis.
- To determine if enzyme activity normalizes after clinical recovery.
Summary:
- Psoriatic skin exhibits significantly heightened redox processes.
- Activity of specific respiratory chain enzymes is altered.
- These enzymatic disturbances remain even post-clinical recovery, suggesting persistent metabolic dysfunction.
Impact:
- Highlights the role of oxidative stress and mitochondrial dysfunction in psoriasis.
- Suggests potential therapeutic targets related to redox balance and enzyme activity.
- Provides insight into the long-term cellular changes associated with psoriasis.