Urodynamic effects of oral benzilonium bromide in healthy subjects

Benzilonium bromide (Ulcoban) has been tried in oral administration in 10 healthy volunteers, 5 of whom got the substance in a fast-release form and 5 in a combination of fast- and slow-release preparation. Serum concentration analyses show that the subject after 1 week of treatment has a certain amount of active substance in blood 12 h after the last administration. There is an increase in serum concentration during the morning hours after administration of another dose at least 1 h before breakfast. The serum concentration is higher when the fast-release form is used. We found in the urodynamic investigation, after 1 week of treatment, an effect on detrusor pressures and urinary flow. In micturitions with a large initial bladder volume, when the patient more easily can initiate a micturition, the difference is not statistically significant. When the initial bladder filling is small, it is more difficult to initiate a micturition, and at an initial bladder volume of 200 ml the difference between micturition with and without benzilonium bromide is more marked, especially in urinary flow and detrusor pressures where the differences are statistically significant.