[Effect of levamisole on immunoglobulin secretion into lacrimal fluid in experimental herpetic keratitis]

The effect of levamisol on changes in the level of secretions of IgA and IgG in the lacrimal fluid normally and in experimental herpetic keratitis in rabbits was determined as well as the severity of the clinical condition of the cornea affected with herpes simplex virus in models given levamisol. The results indicate that oral treatment with levamisol increases the secretion of local IgA in the lacrimal fluid of rabbits. In the animals with the cornea infected with herpes simplex virus IgA secretion in the lacrimal fluid increased at the height of the disease despite levamisol therapy whereas IgG secretion at the same time was lower in sick rabbits than in normal animals. Preventive use of levamisol gave positive result upon subsequent infection of rabbits with herpes simplex virus.