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Updated: Aug 3, 2026
09:42
High-Resolution 3D Imaging of Rabies Virus Infection in Solvent-Cleared Brain Tissue
Published on: April 30, 2019
[Pathomorphology of abortive rabies]
Voprosy Virusologii
|January 1, 1981
Summary
Rabies virus can establish a latent infection in mice, with Babes-Negri bodies occasionally detected long after acute illness. This suggests some rabies cases may become dormant.
Area of Science:
- Virology
- Neuroscience
- Immunology
Context:
- Rabies virus infection in animal models.
- Presence and significance of Babes-Negri bodies.
- Pathogenesis of rabies, including abortive and latent forms.
Purpose:
- To investigate the presence and persistence of Babes-Negri bodies in mice with acute and abortive rabies.
- To explore the potential for latent rabies virus infection.
Summary:
- Babes-Negri bodies were frequently observed in the cerebral neurons of mice with acute street rabies virus infection up to day 5.
- In mice with abortive rabies, occasional Babes-Negri bodies were found in the central nervous system (CNS) up to 240 days post-infection.
- These mice exhibited mild CNS lesions, high antibody titers, and no detectable virus, suggesting a latent infection state.
Impact:
- Provides evidence for the establishment of latent rabies virus infections in a mouse model.
- Highlights the diagnostic challenge of detecting persistent rabies virus.
- Informs understanding of rabies virus persistence and host immune response.
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