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Decrease of vascular angiotensin sensitivity by L-dopa during human pregnancy

H Kaulhausen, T Oney, R Feldmann

    American Journal of Obstetrics and Gynecology
    |July 15, 1981
    PubMed
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    Levodopa (L-dopa) significantly reduced pregnant women's vascular sensitivity to angiotensin II. This finding suggests L-dopa may help manage pregnancy-induced hypertension.

    Area of Science:

    • Pharmacology
    • Obstetrics
    • Cardiovascular Physiology

    Background:

    • Pregnancy can induce hypertension, posing risks to mother and fetus.
    • Angiotensin II plays a key role in regulating blood pressure.
    • Levodopa (L-dopa) is a medication primarily used for Parkinson's disease.

    Purpose of the Study:

    • To investigate the effect of Levodopa (L-dopa) on vascular sensitivity to angiotensin II in pregnant subjects.
    • To explore potential therapeutic applications of L-dopa in managing pregnancy-induced hypertension.

    Main Methods:

    • 27 pregnant subjects (21 treated, 6 controls) participated.
    • Vascular responsiveness to angiotensin II amide was measured.
    • L-dopa was administered orally at doses of 500 to 1,000 mg.

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    Main Results:

    • A 1,000 mg oral dose of L-dopa significantly decreased vascular responsiveness to angiotensin II.
    • The angiotensin pressor dose increased from 16.9 +/- 5.0 to 19.6 +/- 4.5 ng.kg-1.min-1.
    • Control subjects showed an increased vasopressor response to angiotensin without L-dopa.

    Conclusions:

    • L-dopa reduces angiotensin II sensitivity in pregnant women.
    • Potential mechanisms include sympathetic inhibition, reduced peripheral resistance, diuresis, and altered hypothalamic dopaminergic activity.
    • Long-term L-dopa or bromocriptine treatment may help manage pregnancy-induced hypertension.