Related Experiment Video
Updated: Jul 10, 2026

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
Effects and interactions of prostaglandins E1 and E2 on human chorionic plate arteries
Abstract:
Helically cut strips of human chorionic plate arteries were maintained in a physiologic salt solution in vitro while isotonic measurements of contraction were made. The arterial strips were exposed to two prostaglandins, PGE1 and PGE2, added cumulatively to the tissue baths. The effects and interactions of these two prostaglandins were examined. PGE1 had a dose-dependent relaxatory effect on the strips at low concentrations, but contracted them at higher concentrations. PGE2, on the other hand, only induced contraction. The addition of a low concentration of PGE2 inhibited the relaxatory response to PGE1 in approximately half the tissue strips. The contractile response was enhanced in all strips. Conversely, a low concentration of PGE2. The suggestion is made that, in the human term placenta, PGE1 and PGE2 may act in concert as part of the regulatory mechanism for fetoplacental.
More Related Videos
Related Concept Videos
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Acute Inflammation III: Local and Systemic Effects

