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Multifocal primary ocular and central nervous system malignant lymphoma
Annals of Ophthalmology
|May 1, 1981
Summary
Malignant lymphomas infiltrated the eyes and brain, causing vision loss and neurological decline. Autopsy confirmed lymphoma in the central nervous system but found no systemic involvement.
Area of Science:
- Ophthalmology
- Neurology
- Oncology
Background:
- Posterior uveitis can present with varied etiologies.
- Neurologic deterioration necessitates thorough investigation.
Observation:
- A patient presented with bilateral posterior uveitis and rapid neurologic decline.
- Obstructive hydrocephalus was noted due to cerebellar vermis enlargement.
Findings:
- Autopsy revealed multifocal malignant lymphoma infiltration in the eyes, brain, and cerebellum.
- No evidence of systemic lymphoma was detected.
Implications:
- Highlights the potential for primary CNS lymphoma to manifest initially with ocular and neurological symptoms.
- Underscores the importance of considering lymphoma in cases of unexplained uveitis and neurological deterioration.
- Suggests that ocular and neurological findings can precede systemic detection of lymphoma.