An unusual family with retinoblastoma

Reported here is an unusual family with retinoblastoma. The father has spontaneously regressed, bilateral, multifocal retinoblastoma with complete preservation of vision. Three of his six children have had bilateral retinoblastoma requiring bilateral enucleation. At least two of these three children have an associated mental and physical retardation. Chromosome number 13 in this family was normal.