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Related Experiment Videos

Ionic fluoride: a study of its physiological variation in man

D C Cowell, W H Taylor

    Annals of Clinical Biochemistry
    |March 1, 1981
    PubMed
    Summary

    Serum fluoride levels in individuals without fluoridated water increase with age and vary by time of day. Bone metabolism may shift in adulthood, and women show higher peak serum fluoride after sodium fluoride intake.

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    Area of Science:

    • Biochemistry
    • Human Physiology
    • Environmental Health

    Background:

    • Serum ionic fluoride concentrations are influenced by various factors.
    • Understanding fluoride levels is crucial for assessing potential health impacts.
    • Baseline fluoride data from non-fluoridated areas are essential for comparison.

    Purpose of the Study:

    • To determine normal serum ionic fluoride concentrations in individuals from non-fluoridated water areas.
    • To investigate the relationship between serum fluoride, age, and time of day.
    • To examine renal fluoride handling and the pharmacokinetic profile of sodium fluoride ingestion.

    Main Methods:

    • Analysis of serum ionic fluoride in 497 individuals.
    • Correlation analysis with age and time of day.
    • Renal clearance studies and oral sodium fluoride loading tests.

    Main Results:

    • Serum fluoride ranged from 0.25 to 2.20 micromol F-/L, positively correlated with age (r=0.31).
    • Serum fluoride levels exhibited diurnal variation, peaking at 2200.
    • Renal fluoride clearance was 19.5-44.0 ml/min; tubular reabsorption was 61.5-86.5%. Peak serum fluoride after ingestion was higher in women.

    Conclusions:

    • Age and time of day are significant factors influencing serum fluoride levels.
    • Observed patterns suggest potential age-related changes in bone metabolism.
    • Sex influences the absorption and peak serum levels of ingested fluoride.

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