Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

HLA system and affective disorders: a sibship genetic study

E Smeraldi, F Negri, A M Melica

Tissue Antigens

|October 1, 1978

Summary

Genes near the Human Leukocyte Antigen (HLA) complex may increase susceptibility to affective disorders. This study examined HLA-haplotype assortment in families with these conditions, suggesting a genetic link.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Baseline clinical profile of patients with obstructive hypertrophic cardiomyopathy in the Italian Mavacamten early access program.

International journal of cardiology·2026

Same author

Testis and penile cancers in kidney transplant recipients: A systematic review of epidemiology, treatment options and oncological outcomes by the EAU-YAU Penile and Testis Cancer Working Group.

Actas urologicas espanolas·2025

Same author

Curative immune checkpoint inhibitors therapy in patients with mismatch repair-deficient locally advanced rectal cancer: a real-world observational study.

ESMO open·2024

Same author

Epidemiology and clinics of mushroom poisoning in Northern Italy: A 21-year retrospective analysis.

Human & experimental toxicology·2017

Same author

Abnormal brain oscillations persist after recovery from bipolar depression.

European psychiatry : the journal of the Association of European Psychiatrists·2017

Same author

Cognitive remediation and functional improvement in schizophrenia: Is it a matter of size?

European psychiatry : the journal of the Association of European Psychiatrists·2016

Area of Science:

Genetics
Immunogenetics
Psychiatric Genetics

Background:

Affective disorders represent a significant public health concern with complex etiologies.
The Human Leukocyte Antigen (HLA) chromosomal region is known for its role in immune regulation and has been implicated in various complex diseases.

Purpose of the Study:

To investigate HLA-haplotype zygotic assortment in families with multiple cases of affective disorders.
To explore the potential role of genes within the HLA region in susceptibility to affective disorders.
To test the mode of inheritance of a hypothesized susceptibility gene.

Main Methods:

Analysis of HLA-haplotype zygotic assortment in 21 families with multiple affective disorder cases.
Examination of 19 sibling pairs discordant for affective disorders.
Statistical assessment of HLA-haplotype sharing among affected individuals.

Main Results:

Observed excess similarity in HLA-haplotypes between affected siblings.
This finding suggests the presence of genes in the HLA chromosomal region influencing susceptibility to affective disorders.
Initial testing of the mode of inheritance for a hypothetical susceptibility gene was conducted.

Conclusions:

The study provides evidence supporting the hypothesis that genes in the HLA region contribute to affective disorder susceptibility.
Further research is warranted to identify specific genes and elucidate their mechanisms of action.
Understanding the genetic underpinnings of affective disorders can inform future diagnostic and therapeutic strategies.

Related Experiment Videos