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[Gentamicin concentration in the blood and lung tissue of children with bronchopulmonary pathology]
Insights
Intramuscular gentamicin effectively reached therapeutic levels in pediatric lung tissue for most patients. However, children with congenital lung defects showed lower initial lung gentamicin levels compared to those with acquired conditions.
Area of Science:
- Pediatric Surgery
- Pharmacokinetics
- Infectious Diseases
Background:
- Bronchiectasis, destructive pneumonia, and pleural tumors are serious pediatric lung conditions.
- Effective antibiotic penetration into lung tissue is crucial for treating these infections.
- Gentamicin is a commonly used antibiotic for bacterial infections.
Purpose of the Study:
- To investigate gentamicin concentrations in pediatric lung tissue and blood serum.
- To compare gentamicin levels in patients with congenital versus acquired lung diseases.
- To determine if intramuscular gentamicin achieves therapeutic levels in lung tissue for pediatric surgical patients.
Main Methods:
- Studied gentamicin levels in lung tissue and blood serum of pediatric patients undergoing surgery.
- Administered gentamicin intramuscularly at a dose of 3 mg/kg before operation.
- Measured antibiotic levels at 1 and 2 hours post-administration.
Main Results:
- Intramuscular gentamicin achieved sufficient lung tissue levels to inhibit most isolated microbes.
- In patients with congenital lung defects, lung tissue gentamicin levels were sub-therapeutic at 1 hour post-administration.
- By 2 hours, gentamicin levels in lung tissue of patients with congenital defects reached levels seen in those with acquired bronchopulmonary disease.
Conclusions:
- Intramuscular gentamicin administration can achieve therapeutic concentrations in pediatric lung tissue.
- Congenital lung defects may affect initial gentamicin distribution, requiring further monitoring.
- The timing of gentamicin administration relative to surgery is important for optimal therapeutic effect in pediatric lung infections.
Abstract:
The gentamicin levels in the lung tissue and blood serum of children operated on for bronchiectasis, destructive pneumonia and pleural tumors were studied. The antibiotic was administered intramuscularly in a dose of 3 mg/kg before the operation. The results showed that intramuscular injections of gentamicin provided the antibiotic levels in the lung tissue sufficient for the growth inhibition of the majority of the microbes isolated from such patients. In the patients with congenital developmental defects of the lungs, the level of the antibiotic in the lung tissue 1 hour after its administration was lower than the therapeutic one, while its blood serum levels were high. By the 2nd hour the gentamicin levels in the lung tissue reached those in the patients with acquired bronchopulmonary disease.