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Related Experiment Videos

Reduction in alternative complement pathway mediated C3 conversion following burn injury

A B Bjornson, H S Bjornson, W A Altemeier

    Annals of Surgery
    |August 1, 1981
    PubMed
    Summary

    Burn injury impairs the alternative complement pathway, reducing C3 conversion for 50 days. This immune system abnormality, linked to injury severity and infection, may stem from a serum inhibitor.

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    Area of Science:

    • Immunology
    • Complement System
    • Burn Injury Research

    Background:

    • Burn injuries trigger complex immune responses.
    • The alternative complement pathway plays a crucial role in innate immunity.
    • Previous studies suggested complement system abnormalities post-burn.

    Purpose of the Study:

    • To investigate the alternative complement pathway abnormality in burn injury patients.
    • To quantify C3 conversion rates in burn patients compared to healthy controls.
    • To identify factors influencing the complement abnormality and its potential cause.

    Main Methods:

    • Measured C3 conversion using inulin and cobra venom factor in serum samples.
    • Analyzed serial serum samples from 18 burn patients over 50 days post-burn.

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  • Compared C3 conversion rates between burn patients and 25 healthy controls.

    • Main Results:

    • Burn patients showed significantly decreased C3 conversion for 50 days post-injury.
    • The reduction was most pronounced in patients with large full-thickness burns and infections.
    • The abnormality's severity did not correlate with pneumonia or predict fatal outcomes.

    Conclusions:

    • Burn injury induces a significant, prolonged impairment of the alternative complement pathway.
    • A serum inhibitor with cellulose affinity/inactivation properties is suggested as the cause.
    • This finding has implications for understanding burn patient susceptibility to infection.