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Histamine binding proteins in allergic diseases
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1980
Summary
Patients with infectious bronchial asthma show impaired histamine inactivation. However, histamine binding by serum proteins is normal in hay fever and Quincke's edema, suggesting specific mechanisms in different allergic disorders.
Area of Science:
- Immunology
- Allergology
- Biochemistry
Background:
- Allergic disorders involve complex immune responses.
- Histamine plays a key role in allergic reactions.
- Serum proteins are involved in histamine metabolism.
Purpose of the Study:
- To investigate histamine binding by serum proteins in allergic individuals.
- To identify potential defects in histamine inactivation in specific allergic conditions.
Main Methods:
- Analysis of histamine binding capacity of serum proteins.
- Comparison between patients with allergic disorders and healthy subjects.
Main Results:
- A defect in histamine inactivation was identified in patients with infectious bronchial asthma.
- Histaminopexy (histamine binding) was not impaired in patients with hay fever.
- Histaminopexy was also not impaired in patients with Quincke's edema.
Conclusions:
- Infectious bronchial asthma is associated with impaired histamine inactivation.
- Hay fever and Quincke's edema do not appear to involve defects in histamine binding by serum proteins.
- These findings suggest distinct pathophysiological mechanisms in different allergic diseases.