Topographical and cytological localization of iron in rat and monkey brains

The topographical localization of endogenous iron in rat and monkey brains coincides with the striato-pallido-nigral and the cerebellar corticonuclear pathways. EM observation reveals that iron is located in the soma and processes of glial cells and, above all, in the inner and outer loop of the myelin sheets. This raises the question of whether iron intervenes in some GABAergic systems.