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The fragile site at 16q22, distamycin A, and the normal pachytene structure of chromosome 16: some possible
Cytogenetics and Cell Genetics
|January 1, 1981
Abstract:
It is possible to interpret the fragile site at 16q22 as an exaggerated expression of normal structure observed at pachytene, and to interpret the potential for such expression as a heritable trait. Exposure of cells from affected individuals to distamycin A in vitro may function to facilitate realization of this potential where the trait is not expressed spontaneously.