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Retrospective study in 430 patients with Hodgkin's disease (1965-1974)
Insights
This retrospective study of 430 Hodgkin
Area of Science:
- Oncology
- Clinical Medicine
- Medical Research
Background:
- Hodgkin's disease is a malignant lymphogranuloma.
- A Complex Rationalisation Brigade was formed for diagnosis and therapy.
Purpose of the Study:
- To present results of a retrospective study on Hodgkin's disease.
- To analyze patient characteristics, clinical data, and therapeutic outcomes.
Main Methods:
- Retrospective analysis of 430 Hodgkin's disease patients.
- Data treatment using a digital computer.
- Evaluation of radiotherapy, cytostatic therapy, and combination therapy.
Main Results:
- 5-year survival rate was 41% (33% in the first 5 years, 47% in the second 5 years).
- Mediastinal and neck lymph nodes were most frequently involved.
- Relapse depended on irradiation time and dose distribution.
- Lesions above the diaphragm had a better prognosis than subdiaphragm lesions.
Conclusions:
- Therapeutic outcomes for Hodgkin's disease were evaluated.
- Prognosis is influenced by lymph node involvement location.
- Further analysis of irradiation parameters may improve outcomes.
Abstract:
The authors from 11 institutions in the Czech Socialist Republic, grouped into a Complex Rationalisation Brigade for the diagnosis and therapy of the malignant lymphogranuloma, present results of a retrospective study in 430 patients with Hodgkin's disease. The results were obtained after the data treatment on a digital computer and concern with a general characteristic of the group of patients, that involved 57,2% men and 42,8% women with a peak of the age distribution between 20 and 30 years and a second peak between 60 and 70 years. In the clinical data there is an analysis of the rate of occurring the lesion in particular groups of nodes, where the nodes of mediastinum and of the neck were involved most frequently. In the therapeutic procedures the radiotherapy, cytostatic therapy and their combination are evaluated. The 5-year survival in the whole group is of 41%. Out of this, in the first five years of the period of interest and in the second five years, the numbers of the surviving patients were of 33 and 47% respectively. In the Tables, there are complete remissions, mean times of the remission and longest time of the remission for different methods of the therapy. When evaluating the relapse of the disease, it was possible to observe not only the dependence on the total time of irradiation but also on the time distribution of the dose. The patients with involved nodes above the diaphragm have a better prognosis than those with lesions of nodes in the subdiaphragm region.