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Stimulation of retinal adenylate cyclase by vasoactive intestinal peptide (VIP)
European Journal of Pharmacology
|March 12, 1981
Abstract:
The effects of vasoactive intestinal peptide (VIP), secretin and glucagon on retinal adenylate cyclase were studied in rabbit, rat and calf retinas. The results demonstrate the presence of a highly active VIP sensitive adenylate cyclase in mammalian retina. The effects are not enhanced by the guanine nucleotide analog 5'-guanylylimidodiphosphate (Gpp(NH)p). Glucagon and secretin also caused significant increases in retinal adenylate cyclase activity although, in general, the magnitude of these effects was less than that of VIP.