Polymorphism of serum protein in guinea pigs of inbred strains

Three fractions of prealbumin tentatively designated as PA I, II and III were separated by starch gel electrophoresis of sera of inbred guinea pig strains 2 and 13. Migration of PA II in strain 13 was faster than that in strain 2. PA II in F1 hybrid between strains 2 and 13 showed a single broad band approximately twice the width of each strain. Migrations of PA II in other 10 inbred strains of JY series were the same as that of strain 2, except for one strain, JY-8, which showed the same pattern as in strain 13. Thus the PA II migration seemed to be of codominant inheritance and a useful biochemical marker for identification of inbred strains of guinea pigs.