Modulation of lymphocyte stimulation by the vitreous body. A new concept in ocular immunology

The modulating properties of the vitreous body on lymphocyte stimulation has been investigated in vitro. Vitreous hyaluronic acid suppresses lymphocyte stimulation, depending on the physicochemical properties of the biopolymer, by reducing direct and indirect cell-cell interaction. The presence of a lymphocyte stimulation enhancing factor has been demonstrated, and the name ocular lymphocyte modulating factor (OLMF) has been assigned. The potentially basic importance of OLMF for the general immune response of the body has been outlined.