pHresh 3.5: a new low pH liquid skin cleanser

Area of Science:

• Dermatology
• Cosmetic Science
• Clinical Research

Background:

• Skin cleansers play a crucial role in dermatological care.
• Maintaining skin barrier function and managing conditions like acne and oiliness requires appropriate cleansing agents.
• Existing cleansers vary in pH, potentially impacting skin health and treatment compatibility.

Purpose of the Study:

• To evaluate the safety and efficacy of pHresh 3.5, a novel low pH liquid skin cleanser.
• To assess its mildness, degreasing capabilities, and compatibility with concurrent acne treatments.
• To determine its effect on pre-existing skin irritation.

Main Methods:

• Four clinical studies were conducted, including predictive patch tests of 5- and 21-day durations.
• Efficacy as a degreasing agent was assessed over a 4-week period.
• Compatibility with tretinoin was evaluated in acne patients using the cleanser daily for one month.

Main Results:

• pHresh 3.5 was rated mild in predictive patch tests compared to four other cleansers.
• The cleanser demonstrated effective degreasing, particularly in individuals with severe facial oiliness.
• No incompatibility was observed between pHresh 3.5 and tretinoin during daily use.
• The use of pHresh 3.5 did not impede the resolution of pre-existing skin irritation.

Conclusions:

• pHresh 3.5 is a safe and effective low pH liquid skin cleanser.
• Its mildness, degreasing efficacy, and compatibility with acne treatments make it a suitable option for various skin types and conditions.
• The cleanser supports skin health by not hindering the resolution of irritation.