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Electrophoretic analysis of human endometrial proteins

An analysis of the protein composition of the human endometrium was undertaken using sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis. The peak area of a protein with a molecular weight of 48,000 was significantly elevated in the secretory compared with the proliferative endometrium, while the peak area of another protein with a molecular weight of 41,000 was significantly reduced in the late proliferative and secretory endometrium compared with the early proliferative endometrium. A third protein with a molecular weight of 26,000 was detected predominantly in the secretory endometrium. The physiological implications of these findings are discussed.

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