Protein binding of chlorpromazine in cerebrospinal fluid and serum

The binding of chlorpromazine (CPZ) to proteins in human cerebrospinal fluid (CSF) was measured by equilibrium dialysis. In CSF from schizophrenic patients binding of CPZ was found to vary by between 19 and 72%. There was no correlation between the degree of binding and the total amount of protein in the CSF. When CPZ was equilibrated between CSF and serum in vitro almost the same distribution was found as obtained in vivo in drug-treated patients.