Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of length changes on bronchial diameters

R E Hyatt, K P Offord, S J Lai-Fook

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |June 1, 1981
    PubMed
    Summary

    Bronchial length changes affect airway diameter and maximal expiratory flow (Vmax) differently across species. Human airway Vmax calculations can be inaccurate due to these length-dependent effects, especially in older adults.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Recruitment of House Staff into Anesthesiology: Factors Responsible for House Staff Selecting Anesthesiology as a Career and Individual Training Program.

    The journal of education in perioperative medicine : JEPM·2016
    Same author

    Premorbid personality characteristics in Alzheimer's disease: an exploratory case-control study.

    Behavioural neurology·2014
    Same author

    Impaired lung compliance and DL,CO but no restrictive ventilatory defect in sarcoidosis.

    The European respiratory journal·2010
    Same author

    Deformation of a flexible disk bonded to an elastic half space-application to the lung.

    Journal of biomechanical engineering·2009
    Same author

    Timely levodopa (LD) administration prolongs survival in Parkinson's disease.

    Parkinsonism & related disorders·2008
    Same author

    Effect of pancreatic and leukocyte elastase on hydraulic conductivity in lung interstitial segments.

    Journal of applied physiology (Bethesda, Md. : 1985)·2004

    Area of Science:

    • Pulmonary Physiology
    • Respiratory Mechanics
    • Comparative Anatomy

    Background:

    • Airway caliber is crucial for regulating airflow within the respiratory system.
    • Previous research has primarily focused on the pressure-diameter relationships of airways without fully considering the impact of length variations.

    Purpose of the Study:

    • To investigate the influence of physiological length changes on the pressure-diameter (PD) behavior of large intrapulmonary airways in pigs, dogs, and humans.
    • To estimate the impact of these length-induced alterations on maximal expiratory flow (Vmax) using the wave-speed theory.
    • To assess the age-dependency of these effects in human airways.

    Main Methods:

    • Studied excised intrapulmonary bronchi from pigs, dogs, and humans.
    • Measured pressure-diameter (PD) relationships under varying lengths.
    • Applied the wave-speed theory to predict maximal expiratory flow (Vmax).

    Main Results:

    • Bronchial length changes did not affect PD behavior in pigs.
    • Lengthening reduced dog bronchial diameter but preserved PD curve shape.
    • In humans, lengthening decreased diameter at high transmural pressures, impacting Vmax calculations.
    • In situ PD curves overestimated dog Vmax by 16% and underestimated human Vmax by 17%.
    • Human effects were more pronounced in individuals over 40 years old.

    Conclusions:

    • Physiological length changes significantly impact the pressure-diameter behavior and maximal expiratory flow (Vmax) of human airways, with notable age-related differences.
    • Standard PD curves may lead to inaccurate Vmax estimations in clinical settings, particularly for older populations.
    • Comparative analysis reveals species-specific responses to airway lengthening, highlighting the complexity of respiratory mechanics.

    Related Experiment Videos