Effect of probenecid on response to bumetanide in man

We administered 0.5-and 1.0-mg doses of bumetanide intravenously to eight normal subjects with and without pretreatment with probenecid. Probenecid did not effect either the cumulative response or the time course of response of bumetanide. These results are in contrast to results reported in dogs but consistent with similar studies in cats. The data imply that probenecid and potentially other exogenous or endogenous organic acids do not affect the renal handling of bumetanide in normal man.