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Side effects of xenon inhalation
Journal of Computer Assisted Tomography
|August 1, 1981
Summary
Xenon-oxygen inhalation (28-47%) was generally well-tolerated in 12 studies. One subject experienced severe side effects, highlighting the need to identify individuals who may have reduced tolerance to xenon.
Area of Science:
- Anesthesiology
- Pharmacology
- Respiratory Medicine
Background:
- Xenon is an inert gas with anesthetic properties.
- Previous research suggests xenon's potential therapeutic applications.
- Understanding xenon's safety profile is crucial for clinical use.
Purpose of the Study:
- To review short- and long-term side effects of premixed xenon-oxygen inhalation.
- To assess the general tolerability of xenon in human subjects.
- To identify potential indicators of reduced xenon tolerance.
Main Methods:
- Systematic review of 12 studies involving xenon-oxygen inhalation.
- Analysis of reported adverse events and subject tolerance.
- Evaluation of short-term and long-term side effects.
Main Results:
- Most subjects tolerated xenon-oxygen mixtures (28-47%) without adverse effects.
- One subject reported severe dysesthesias and unresponsiveness.
- No other significant short- or long-term side effects were documented.
Conclusions:
- Xenon-oxygen inhalation appears to be generally safe.
- Further research is needed to identify predictors of xenon intolerance.
- Investigating early indicators for reduced tolerance is recommended for future human studies.