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Polymorphonuclear functions and aging in humans

J Corberand, F Ngyen, P Laharrague

    Journal of the American Geriatrics Society
    |September 1, 1981
    PubMed
    Summary
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    Normal aging impairs polymorphonuclear leukocyte (PMN) function, particularly chemotaxis and Candida-killing activity in older adults. Some functions like adherence increase with age, while others show complex changes.

    Area of Science:

    • Immunology
    • Gerontology
    • Cellular Biology

    Background:

    • Polymorphonuclear leukocytes (PMNs) are crucial for innate immunity.
    • The impact of normal aging on PMN functional capabilities requires detailed investigation.

    Purpose of the Study:

    • To assess age-related changes in the functional capacity of PMNs in healthy individuals.
    • To identify specific PMN functions affected by the aging process.

    Main Methods:

    • Evaluated 6 PMN function tests in 217 healthy subjects aged 20-97 years.
    • Subjects were categorized into 7 age groups with equal male and female representation.

    Main Results:

    • Decreased PMN chemotaxis observed in the 80+ age group.

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  • Increased PMN adherence noted after age 70, peaking after age 80.
  • Diminished Candida-killing activity appeared in the 60+ group, worsening with advanced age.
  • NBT dye reduction capability decreased up to age 70-79, then increased post-80.
  • Spontaneous migration and endocytosis remained unchanged.

    • Conclusions:

    • Normal aging significantly impairs specific PMN functions, including chemotaxis and pathogen killing.
    • Age-related alterations in PMN function may be influenced by systemic humoral factors.
    • Defective PMN function is a potential consequence of the broader aging process.