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Related Experiment Videos

Thermal hardness coefficient of tablets

E L Parrott

    Journal of Pharmaceutical Sciences
    |March 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Tablet hardness is largely unaffected by temperature fluctuations within typical storage conditions, simplifying quality control. However, sustained-release formulations exhibit different temperature-dependent behaviors.

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    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science

    Background:

    • Tablet hardness is a critical quality attribute affecting drug dissolution and bioavailability.
    • Understanding the impact of environmental factors like temperature on tablet properties is essential for pharmaceutical development and storage.

    Purpose of the Study:

    • To investigate the effect of varying temperatures on the hardness of conventional compressed tablets.
    • To determine if temperature control is necessary during tablet hardness testing.
    • To compare the temperature sensitivity of conventional tablets with nonconventional (sustained-release) formulations.

    Main Methods:

    • Evaluated the hardness of 10 different commercial compressed tablets.
    • Tested tablet hardness at four distinct temperatures: -25, 0, 24, and 50 degrees Celsius.

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  • Compared hardness measurements across the different temperature points.

    • Main Results:

    • Tablet hardness demonstrated minimal sensitivity to temperature changes within the tested range, particularly between 0 and 50 degrees Celsius.
    • Conventional compressed tablets maintained consistent hardness across a wide temperature spectrum.
    • Nonconventional sustained-release tablets exhibited different hardness behaviors in response to temperature variations.

    Conclusions:

    • Temperature control is generally not required for accurate tablet hardness measurements of conventional compressed tablets under normal conditions.
    • The findings simplify quality control procedures for standard tablet formulations.
    • Further investigation is warranted for sustained-release tablet formulations due to their distinct temperature sensitivity.