Degradation of propildazine in water

Propildazine degradation in water at pH 7.4 was studied under aerobic conditions. Three main products were isolated by column chromatography and identified on the basis of IR, UV, and NMR spectroscopy and mass spectrometry and by comparison with synthetic samples. Drug disappearance in water was monitored by UV spectroscopy and was concentration, pH, temperature, and oxygen dependent. Propildazine degradation also was followed in methanol at various pH values.