Inhibition of histidine decarboxylase by imidazole derivatives

A series of 4-imidazolylmethyl arylsulfides, sulfoxides, and sulfones and two carbon isosteres of 4-imidazolylmethylphenyl sulfide (I) were synthesized and tested for inhibition of histidine decarboxylase from rat stomach. None of these analogs of I met the criterion of a potent and specific inhibitor of histidine decarboxylase.