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Pulsatile venous flow in extracorporeal circulation

O Nishimura, T Sakurai, M Takimoto

    Japanese Heart Journal
    |May 1, 1981
    PubMed
    Summary
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    Pulsatile venous flow enhances microcirculation by increasing oxygen consumption, particularly when venous pressure is low. This effect aids in opening capillaries, improving blood flow in collapsed or normal venous pressure stages.

    Area of Science:

    • Physiology
    • Microcirculation Research
    • Vascular Dynamics

    Background:

    • Microcirculation is crucial for tissue oxygenation and nutrient exchange.
    • Venous pressure significantly influences microcirculatory function and blood flow dynamics.
    • Understanding the impact of pulsatile venous flow is key to managing circulatory conditions.

    Purpose of the Study:

    • To investigate the effects of pulsatile venous flow on microcirculation.
    • To determine the influence of varying venous pressures on these effects.
    • To explore the potential of venous pulsation in improving capillary perfusion.

    Main Methods:

    • Regional perfusion model in canine hind legs.
    • Experimental manipulation of venous pressure to simulate collapsed (-18 cmH2O), normal (+2 cmH2O), and congestive (+10 cmH2O) stages.

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  • Measurement of oxygen consumption ratio and resistance ratio to assess microcirculatory response.

    • Main Results:

    • In collapsed and normal venous pressure stages, venous pulsation significantly increased oxygen consumption ratio.
    • Venous pulsation effectively suppressed resistance ratio rise only in the collapsed stage.
    • No significant effect of venous pulsation was observed in the congestive stage (venous pressure +10 cmH2O).

    Conclusions:

    • Pulsatile venous flow enhances microcirculation by increasing oxygen consumption, especially at lower venous pressures.
    • Venous pulsation's ability to suppress resistance suggests improved capillary recruitment in collapsed states.
    • The findings indicate that venous pulsation may be beneficial for microcirculatory function when venous pressure is below +2 cmH2O.