Effects of fluphenazine hydrochloride on the bone-marrow cells of Swiss mice

The possible mutagenic effects induced by fluphenazine hydrochloride in bone-marrow cells of mice were evaluated by the micronucleus test. Mice were treated orally and intraperitoneally with the drug at dose of 55, 110 and 165 mg/kg and 21.25, 42.50 and 63.75 mg/kg resp. Bone-marrow preparations were made, and the slides were analysed for the presence of micronuclei in developing erythrocytes. Fluphenazine hydrochloride induced a significant dose-dependent increase of micronuclei in polychromatic erythrocytes by oral administration, whereas only a marginal increase was observed at 42.50 and 63.75 mg/kg dose levels by intraperitoneal administration. Further, fluphenazine hydrochloride induced bone-marrow depletion at all dose levels with oral administration only.