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Nuclear envelope invaginations in hamster pyramidal cells during development and aging

M T Buschmann, J S Geoffroy, A LaVelle

    Neurobiology of Aging
    |January 1, 1981
    PubMed
    Summary

    Nuclear envelope invaginations in hamster frontal cortex pyramidal cells persist from development through aging. Their numbers and length increase with age, suggesting sustained high metabolic activity in these neurons.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Developmental Biology

    Background:

    • Nuclear envelope invaginations are observed in certain cell types.
    • Their presence and behavior during neuronal development and aging are not fully understood.

    Purpose of the Study:

    • To investigate the presence and changes in nuclear envelope invaginations in hamster frontal cortex pyramidal cells during development and aging.
    • To correlate these morphological changes with age and infer potential metabolic activity.

    Main Methods:

    • Observation of nuclear envelope invaginations in pyramidal cell nuclei of hamster frontal cortex.
    • Morphometric analysis to quantify the number and length of invaginations per unit of nuclear area.
    • Correlation analysis between invagination metrics and animal age.

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    Main Results:

    • Nuclear envelope invaginations were detected in pyramidal cell nuclei starting at 10 days of development.
    • These invaginations persisted into adulthood and throughout subsequent aging, unlike in other cell types.
    • A significant increase in both the number and length of invaginations was observed.
    • This increase showed a positive correlation with age up to 500 days.

    Conclusions:

    • Nuclear envelope invaginations in hamster frontal cortex pyramidal neurons are a persistent feature from development into old age.
    • The age-dependent increase in invaginations suggests sustained high metabolic activity in these neurons beyond the initial growth phase.