Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Middle ear mucosa in chronic effusions

T Palva, J Mäkinen, J Rinne

    ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties
    |January 1, 1981
    PubMed
    Summary

    Middle ear mucosa in chronic effusion shows mucus production and immune cell infiltration. Fibrotic changes and inflammation suggest potential irreversibility, highlighting the impact of chronic irritation and infection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Increasing climacteric symptoms in untreated perimenopausal Finnish women: a 10-year cohort study.

    Climacteric : the journal of the International Menopause Society·2023
    Same author

    Educators' occupational well-being in health and social care education.

    Occupational medicine (Oxford, England)·2022
    Same author

    Stress urinary incontinence after hysterectomy: a 10-year national follow-up study.

    Archives of gynecology and obstetrics·2022
    Same author

    Effect of the 2018 European drought on methane and carbon dioxide exchange of northern mire ecosystems.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2020
    Same author

    Primary familial brain calcification linked to deletion of 5' noncoding region of SLC20A2.

    Acta neurologica Scandinavica·2016
    Same author

    Metal removal from Municipal Solid Waste Incineration fly ash: A comparison between chemical leaching and bioleaching.

    Waste management (New York, N.Y.)·2016

    Area of Science:

    • Otolaryngology
    • Pathology
    • Immunology

    Background:

    • Chronic middle ear effusion (CME) is a common condition requiring intervention.
    • Understanding the mucosal changes in CME is crucial for effective treatment and management.

    Purpose of the Study:

    • To investigate the histopathological and immunological characteristics of middle ear mucosa in patients with chronic mucoid effusion.

    Main Methods:

    • Biopsies of middle ear mucosa were obtained from patients undergoing ventilation tube insertion or reinsertion.
    • Histological examination focused on mucosubstances, goblet cells, subepithelial glands, inflammatory cell infiltration, and fibrotic changes.

    Main Results:

    • Mucosal biopsies revealed a mucus blanket and intracellular mucosubstances.
    • Goblet cell frequency varied, with larger subepithelial glands in longer-duration cases.
    • Mononuclear cells and lymphocyte follicles were common in the propria; fibrotic changes were present in one-third of specimens.
    • Polymorphonuclear leukocytes were absent in the mucosa, but present in effusion, suggesting infection.

    Conclusions:

    • Middle ear mucosal response involves immune cells and may result from chronic irritation by bacteria and immune complexes.
    • Significant fibrotic changes in the propria may indicate irreversible disease.
    • The findings underscore the role of chronic inflammation and infection in the pathogenesis of CME.

    Related Experiment Videos