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Published on: January 18, 2017
Aspirin inhibits Ca2+-stimulated fatty acid release from human washed platelets
Abstract:
Ca2+ at 2mM concentration stimulates the release of saturated and unsaturated fatty acids from intact washed platelets incubated at 37 degrees C with stirring. Aspirin at a concentration of 0.4 mM inhibits both cyclo-oxygenase activity and fatty acid efflux induced by Ca2+. Thus, in intact washed platelets, aspirin reduces formation of cyclo-oxygenase products by direct inhibition of the enzyme and by reducing the availability of precursor arachidonate.
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