[Nelson's syndrome. A case report (author's transl)]

Area of Science:

• Endocrinology
• Oncology
• Radiology

Background:

• Nelson syndrome is a rare clinical complication following bilateral adrenalectomy for Cushing's disease.
• It is characterized by the development of a pituitary adenoma with hyperpigmentation and mass effect.

Observation:

• Two cases of Nelson syndrome are presented with typical clinical and laboratory findings.
• Radiological evidence of pituitary tumors was observed in both cases, with plain films and tomography used for assessment.

Findings:

• The study highlights the importance of regular monitoring for pituitary adenoma development in post-adrenalectomy patients.
• Key indicators for early detection include skin pigmentation changes, visual field assessments, and sellar morphology evaluation.

Implications:

• Early detection and management of pituitary adenomas in Nelson syndrome can prevent severe complications.
• This underscores the need for vigilant follow-up protocols in patients treated for Cushing's disease.