Prostaglandin F2 alpha effects on the early mouse embryo

Subcutaneous treatment of pregnant mice with 50, 100 and 200 micrograms PGF 2 alpha on gestational day 5 and 200 micrograms on gestational day 3 or 6 resulted in fetal growth retardation. Litter size was significantly reduced following treatment with 50 micrograms or 100 micrograms PGF 2 alpha on day 6 of pregnancy and the incidence of resorptions was increased following treatment with 50 micrograms on gestational day 6.