Effect of DDT on adipose tissue lipolysis in rat

The effect of acute (600 mg/kg body wt) and chronic (15 mg/kg body wt/day for 45 days) DDT treatments of albino rats on the lipolytic activity of the adipose tissue was studied. There was no effect on the rate of glycerol release on incubation of isolated epididymal fat pads of the treated animals when compared to that of controls. Similarly, in vitro addition of DDT (10(-4) M) to the fat pads did not alter their lipolytic response. Noradrenaline stimulated lipolysis, in fat pads, was also unaffected by in vitro addition of DDT. Basal as well as noradrenaline or caffeine stimulated lipolysis in isolated fat cells also remained unchanged in the presence of DDT over a range of concentrations from 10(-8) M to 10(-4) M.