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[Shortening of interval between first and second TBE vaccination in asthmatic children (author's transl)]
Insights
Asthmatic children can receive the tick-borne encephalitis (TBE) vaccine with a shortened 10-day interval between the first two doses. This accelerated TBE vaccination schedule effectively produced sufficient antibodies and was well-tolerated, showing no increased side effects.
Area of Science:
- Pediatrics
- Immunology
- Vaccinology
Context:
- Asthma is a common chronic respiratory condition in children.
- Tick-borne encephalitis (TBE) is a serious viral infection prevalent in endemic areas.
- Standard TBE vaccination protocols involve specific intervals between doses.
Purpose:
- To evaluate the immunogenicity and safety of an accelerated tick-borne encephalitis (TBE) vaccination schedule in children with asthma.
- To compare the antibody response and side effect profile in asthmatic children receiving TBE vaccine with a 10-day interval versus a standard interval.
Summary:
- 37 children with asthma received two TBE vaccine doses with a 10-day interval.
- Antibody levels were assessed 14 days after the second dose.
- The antibody response and incidence of side reactions were comparable to children vaccinated with the standard 1-3 month interval.
Impact:
- The findings suggest that TBE vaccination can be safely and effectively administered with an accelerated schedule in pediatric asthma patients.
- This accelerated schedule may improve vaccine compliance and timely protection against TBE in this vulnerable population.
- Further research could explore the long-term antibody persistence and efficacy of this accelerated schedule.
Abstract:
37 children suffering from asthma had to be vaccinated against tick-borne encephalitis (TBE) with an interval of only 10 days between the first two vaccinations. Sufficient antibodies were detected in samples taken 14 days after the second injection. No differences were found between the results in this group of asthmatic children and in children who were vaccinated with the usual interval of 1 to 3 months elapsing between the first two injections. The asthmatic children tolerated the vaccination very well, moreover the indicence of side reactions was not different from that of the control group.